购物车
帮助
021-54845833/15800441009
|
Fusion protein corresponding to a region derived from 1-180 amino acids of human HGF |
技术规格
|
Full name: |
hepatocyte growth factor (hepapoietin A; scatter factor) |
|
Synonyms: |
SF; HGFB; HPTA; F-TCF; DFNB39 |
|
Swissprot: |
P14210 |
|
Gene Accession: |
BC063485 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. |
