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Background: |
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009] |
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Applications: |
WB |
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Name of antibody: |
GAB2(Phospho-Ser159) |
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Immunogen: |
Peptide sequence around phosphorylation site of Serine 159(K-S-S(p)-A-P) derived from Human GRB2. |
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Full name: |
GRB2-associated binding protein 2 |
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Synonyms： |
GAB2 |
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SwissProt: |
Q9UQC2 |
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WB Predicted band size: |
74 kDa |
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WB Positive control: |
HT29 cells lysates treated with serum |
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WB Recommended dilution: |
500-1000 |
