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Background: |
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
ITGA4 |
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Immunogen: |
Fusion protein of human ITGA4 |
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Full name: |
integrin subunit alpha 4 |
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Synonyms: |
IA4; CD49D |
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SwissProt: |
P13612 |
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ELISA Recommended dilution: |
2000-5000 |
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IHC positive control: |
Human tonsil |
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IHC Recommend dilution: |
20-100 |
