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相关类别： 一抗
抗 原： ITCH(Phospho-Tyr420)
技术规格
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Background: |
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] |
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Applications: |
IHC |
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Name of antibody: |
ITCH(Phospho-Tyr420) |
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Immunogen: |
Peptide sequence around phosphorylation site of tyrosine 420(F-I-Y(p)-G-N) derived from Human ITCH . |
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Full name: |
itchy E3 ubiquitin protein ligase |
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Synonyms： |
AIF4; AIP4; ADMFD; NAPP1; dJ468O1.1 |
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SwissProt: |
Q96J02 |
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IHC positive control: |
Human brain tissue |
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IHC Recommend dilution: |
50-100 |
