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021-54845833/15800441009
中文名称 : 小鼠抗DCPS单克隆抗体
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Background: |
Eukaryotic cells primarily utilize exoribonucleases and decapping enzymes to degrade their mRNA. DcpS is a scavenger pyrophosphatase that hydrolyzes the residual cap structure following 3' to 5' decay of an mRNA. Following mRNA degradation DcpS releases N-7 methyl guanosine monophosphate and 5'-diphosphate terminated cap or mRNA products. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. HIT proteins are homodimeric and contain two conserved 100-amino-acid HIT fold domains with independent active sites that are each sufficient to bind and hydrolyze cognate substrates. |
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Applications: |
WB, IHC |
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Name of antibody: |
DCPS |
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Immunogen: |
Fusion protein of human DCPS |
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Full name: |
decapping enzyme, scavenger (DCPS) |
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Synonyms: |
ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015 |
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SwissProt: |
Q96C86 |
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IHC positive control: |
carcinoma of human thyroid tissue and human endometrium tissue; human kidney tissue and human lymph node tissue |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
39 kDa |
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WB Positive control: |
HepG2, Hela, SVT2, COS7, PC12, MCF-7 cell lysates |
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WB Recommended dilution: |
1000-5000 |
