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021-54845833/15800441009
中文名称 : 小鼠抗CD22单克隆抗体
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Background: |
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. |
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Applications: |
WB, IHC |
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Name of antibody: |
CD22 |
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Immunogen: |
Fusion protein of human CD22 |
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Full name: |
CD22 molecule (CD22), transcript variant 1 |
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Synonyms: |
SIGLEC-2; SIGLEC2 |
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SwissProt: |
P20273 |
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IHC positive control: |
human lymph node tissue |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
95 kDa |
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WB Positive control: |
HepG2, Hela, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF-7 cell lysates |
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WB Recommended dilution: |
500-2000 |
