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中文名称：兔抗CCDC134多克隆抗体
英文名称： Anti-CCDC134 rabbit polyclonal antibody
别 名： coiled-coil domain containing 134
储 存： 冷冻（-20℃）
宿 主： Rabbit
抗 原： CCDC134
反应种属： Human, Mouse, Rat
标 记 物： Unconjugate
克隆类型： rabbit polyclonal
技术规格
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Background: |
In extracellular secreted form, promotes proliferation and activation of CD8+ T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8+ T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
CCDC134 |
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Immunogen: |
Fusion protein of human CCDC134 |
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Full name: |
coiled-coil domain containing 134 |
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SwissProt: |
Q9H6E4 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer |
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IHC Recommend dilution: |
50-200 |
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WB Predicted band size: |
27 kDa |
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WB Positive control: |
Human fetal liver tissue, 293T cell lysates |
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WB Recommended dilution: |
1000-5000 |
