购物车
帮助
021-54845833/15800441009
中文名称：兔抗BLNK多克隆抗体
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Background: |
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
BLNK |
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Immunogen: |
Fusion protein of human BLNK |
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Full name: |
B-cell linker |
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Synonyms: |
bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65 |
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SwissProt: |
Q8WV28 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer and human gastric cancer |
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IHC Recommend dilution: |
50-300 |
