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中文名称：兔抗BCL2A1多克隆抗体
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Background: |
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
BCL2A1 |
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Immunogen: |
Fusion protein of human BCL2A1 |
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Full name: |
BCL2-related protein A1 |
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Synonyms： |
GRS; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5 |
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SwissProt: |
Q16548 |
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ELISA Recommended dilution: |
2000-5000 |
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IHC positive control: |
Human thyroid cancer |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
20 kDa |
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WB Positive control: |
Mouse testis tissue and hela cells |
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WB Recommended dilution: |
200-1000 |
