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中文名称：兔抗AXIN2多克隆抗体
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Background: |
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
AXIN2 |
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Immunogen: |
Fusion protein of human AXIN2 |
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Full name: |
axin 2 |
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Synonyms： |
AXIL; ODCRCS |
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SwissProt: |
Q9Y2T1 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human thyroid cancer and human brain |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
94 kDa |
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WB Positive control: |
Human ileum adenocarcinoma tissue |
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WB Recommended dilution: |
200-1000 |
