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021-54845833/15800441009
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Background: |
TMPRSS11F is a type-II transmembrane protease, similar to hepsin (TMPRSS1). TMPRSS11F is a member of a larger family of membrane attached serine proteases, a poorly defined group that includes TMPRSS11A, B, C, D, E, F, Hepsin, Corin, Matriptase-1, 2 and 3. TMPRSS11F has a domain structure of an aminoterminal cytoplasmic domain, followed by a transmembrane domain, a SEA domain (Sea urchin sperm protein, Enterokinase, Agrin), a short spacer, then the trypsin-like serine protease domain. The SEA domain is thought to play a role in carbohydrate binding in the analogous protein sequences where it is found, but its role in TMPRSS11F is unclear. The cleavage of the Arg206-Ile207 bond is thought to liberate the catalytic domain. |
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Applications: |
ELISA, WB |
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Name of antibody: |
TMPRSS11F |
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Immunogen: |
Synthetic peptide of human TMPRSS11F |
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Full name: |
transmembrane protease, serine 11F |
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SwissProt: |
Q6ZWK6 |
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ELISA Recommended dilution: |
1000-2000 |
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WB Predicted band size: |
49 kDa |
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WB Positive control: |
Human esophagus and thyroid cancer tissue |
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WB Recommended dilution: |
200-1000 |
