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Background: |
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
TGFBR1 |
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Immunogen: |
Synthetic peptide of human TGFBR1 |
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Full name: |
transforming growth factor, beta receptor 1 |
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Synonyms: |
AAT5; ALK5; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4 |
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SwissProt: |
P36897 |
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IHC positive control: |
Human gastric cancer |
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IHC Recommend dilution: |
100-300 |
