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021-54845833/15800441009
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Background: |
his gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. |
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Applications: |
WB, IHC |
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Name of antibody: |
TCEB3 |
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Immunogen: |
Synthesized peptide derived from internal of human ELOA1. |
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Full name: |
transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) |
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Synonyms： |
EloA; SIII; TCEB3A; SIII p110 |
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SwissProt: |
Q14241 |
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IHC positive control: |
Human breast carcinoma tissue |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
90 kDa |
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WB Positive control: |
Jurkat cells and Huvec cells lysates |
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WB Recommended dilution: |
500-3000 |
