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021-54845833/15800441009
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Background: |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. |
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Applications: |
WB, IHC |
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Name of antibody: |
STAT4 |
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Immunogen: |
Synthetic peptide of human STAT4 (Ab-693) |
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Full name: |
signal transducer and activator of transcription 4 |
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Synonyms： |
SLEB11 |
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SwissProt: |
Q14765 |
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IHC positive control: |
Human breast carcinoma |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
86 kDa |
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WB Positive control: |
Hela, A431 and Jurkat cells |
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WB Recommended dilution: |
500-1000 |
