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Background: |
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. |
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Applications: |
WB |
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Name of antibody: |
SP1 (Phospho-Thr739) |
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Immunogen: |
Synthetic peptide of human SP1 (Phospho-Thr739) |
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Full name: |
Sp1 transcription factor (Phospho-Thr739) |
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SwissProt: |
P08047 |
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WB Predicted band size: |
81 kDa |
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WB Positive control: |
NIH/3T3 cells treated with serum starvation |
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WB Recommended dilution: |
500-1000 |
