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中文名称： 兔抗PRKD1/2/3(Phospho-Ser738/742) 多克隆抗体
英文名称： Anti-PRKD1/2/3(Phospho-Ser738/742) rabbit polyclonal antibody
别 名： PKD; PKCM; PRKCM; PKC-MU
相关类别： 一抗
储 存： 冷冻（-20℃） 避光
宿 主： Rabbit
抗 原： PRKD1/2/3(Phospho-Ser738/742)
反应种属： Human Mouse Rat
标 记 物： Unconjugate
克隆类型： rabbit polyclonal
技术规格
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Background: |
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. |
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Applications: |
WB |
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Name of antibody: |
PRKD1/2/3(Phospho-Ser738/742) |
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Immunogen: |
Peptide sequence around phosphorylation site of Serine738/Serine 742 (E-K-S(p)-F-R-R-S(p)-V-V) derived from Human PKD1/2/3/PKC μ. |
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Full name: |
protein kinase D1/2/3 |
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Synonyms： |
PKD; PKCM; PRKCM; PKC-MU |
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SwissProt: |
Q15139 |
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WB Predicted band size: |
102 kDa |
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WB Positive control: |
A549 cells lysates with PMA |
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WB Recommended dilution: |
500-1000 |
