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021-54845833/15800441009
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Background: |
Human homolog is a cofactor for factor IXa; it involved in blood coagulation. Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Interacts with VWF. VWF binding is essential for the stabilization of F8 in circulation. Secreted protein; extracellular space. Domain F5/8 type C 2 is responsible for phospholipid-binding and essential for factor VIII activity. Defects in F8 are the cause of hemophilia A (HEMA). Belongs to the multicopper oxidase family. |
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Applications: |
IHC, IF |
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Name of antibody: |
F8 |
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Immunogen: |
KLH conjugated synthetic peptide derived from rat factor VIII |
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Full name: |
coagulation factor VIII, procoagulant component |
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SwissProt: |
P00451 |
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ELISA Recommended dilution: |
500-1000 |
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IF Recommended dilution: |
100-500 |
