购物车
帮助
021-54845833/15800441009
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Background: |
One member of the STAT family, Stat3, participates in a wide range of biological processes including nephrogenesis, gliogenesis, hepatogenesis, T cell proliferation, inflammation and oncogenesis. Many of these responses are triggered by the IL-6 family of cytokines, which transduce their vital signals through a common gp130 receptor chain . A novel Stat3-Interacting Protein, StIP1, contains 12 WD40 repeats, which mediate protein-protein interactions . StIP1 exhibits an affinity for members of the JNK family and may play a specific role in regulating Stat3 activation. Overexpression of StIP1 blocks Stat3 activation, nuclear translocation and Stat3-dependent induction of a reporter gene, suggesting that StIP1 regulates the ligand-dependent activation of Stat3, probably by serving as a scaffold protein that promotes the interaction between JNK and the Stat3 substrate. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
ELP2 |
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Immunogen: |
Fusion protein of human ELP2 |
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Full name: |
elongator acetyltransferase complex subunit 2 |
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Synonyms： |
StIP; StIP1; SHINC-2; STATIP1 |
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SwissProt: |
Q6IA86 |
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ELISA Recommended dilution: |
2000-5000 |
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IHC positive control: |
Human liver cancer and human thyroid cancer |
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IHC Recommend dilution: |
50-200 |
