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021-54845833/15800441009
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Background: |
E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
EID1 |
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Immunogen: |
Fusion protein of human EID1 |
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Full name: |
EP300 interacting inhibitor of differentiation 1 |
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Synonyms： |
CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620 |
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SwissProt: |
Q9Y6B2 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human colon cancer and human esophagus cancer |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
21 kDa |
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WB Positive control: |
Mouse heart tissue |
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WB Recommended dilution: |
200-1000 |
