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021-54845833/15800441009
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Background: |
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. |
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Applications: |
ELISA, WB |
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Name of antibody: |
DOK1 |
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Immunogen: |
Fusion protein of human DOK1 |
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Full name: |
docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
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Synonyms： |
P62DOK |
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SwissProt: |
Q99704 |
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ELISA Recommended dilution: |
2000-5000 |
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WB Predicted band size: |
52 kDa |
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WB Positive control: |
Human hepatocellsular carcinoma tissue and Jurkat cells |
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WB Recommended dilution: |
500-2000 |
