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Background: |
DnaJ homolog subfamily B member 1 is a protein that in humans is encoded by the DNAJB1 gene. Heat shock protein 40 (HSP 40) family proteins bind to HSP 70 through their J-domain and regulate the function of HSP 70 by stimulating HSP 70 ATPase activity. HSP 40, also known as DnaJ, functions together with DnaK (HSP 70) and GrpE as a molecular chaperone, involving them in assembly and disassembly of protein complexes, protein folding, renaturation of denatured proteins, prevention of protein aggregation and protein export. HSP 40 stimulates the association between HSC 70 and HIP and translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
DNAJB1 |
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Immunogen: |
Fusion protein of human DNAJB1 |
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Full name: |
DnaJ (Hsp40) homolog, subfamily B, member 1 |
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Synonyms： |
Hdj1; Sis1; HSPF1; Hsp40; RSPH16B |
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SwissProt: |
P25685 |
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ELISA Recommended dilution: |
2000-5000 |
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IHC positive control: |
Human lung cancer and human gastric cancer |
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IHC Recommend dilution: |
25-100 |
