购物车
帮助
021-54845833/15800441009
中文名称： MASP1 抗原（重组蛋白）
英文名称： MASP1 Antigen (Recombinant Protein)
别 名： 3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1
相关类别： 抗原
储 存： 冷冻（-20℃）
概 述
|
Fusion protein corresponding to a region derived from 449-699 amino acids of humanMASP1
|
|
Full name: |
mannan binding lectin serine peptidase 1 |
|
Synonyms: |
3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1 |
|
Swissprot: |
P48740 |
|
Gene Accession: |
BC106945 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. |
