购物车
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021-54845833/15800441009
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Background: |
DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
DEPTOR |
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Immunogen: |
Synthetic peptide of human DEPTOR |
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Full name: |
DEP domain containing MTOR-interacting protein |
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Synonyms: |
DEP.6; DEPDC6 |
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SwissProt: |
Q8TB45 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human thyroid cancer;Human liver cancer |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
46 kDa |
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WB Positive control: |
Human fetal liver tissue lysate |
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WB Recommended dilution: |
200-1000 |
