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中文名称：ITGA4抗原（重组蛋白）
英文名称： ITGA4 Antigen (Recombinant Protein)
别 名： IA4; CD49D
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
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Fusion protein corresponding to a region derived from 756-1032 amino acids of human ITGA4 |
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Full name: |
integrin subunit alpha 4 |
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Synonyms: |
IA4; CD49D |
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Swissprot: |
P13612 |
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Gene Accession: |
BC080190 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. |
