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中文名称： EID1抗原（重组蛋白）
英文名称： EID1 Antigen (Recombinant Protein)
别 名： CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to a region derived from 2-187 amino acids of human EID1 |
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Full name: |
EP300 interacting inhibitor of differentiation 1 |
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Synonyms: |
CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620 |
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Swissprot: |
Q9Y6B2 |
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Gene Accession: |
NP_055150 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator. |
