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Background: |
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
CTLA4 |
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Immunogen: |
Synthetic peptide of human CTLA4 |
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Full name: |
cytotoxic T-lymphocyte associated protein 4 |
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Synonyms: |
CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3 |
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SwissProt: |
P16410 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer and Human ovarian cancer |
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IHC Recommend dilution: |
25-100 |
