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Background: |
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. |
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Applications: |
WB |
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Name of antibody: |
CHEK1(Phospho-Ser301) |
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Immunogen: |
Peptide sequence around phosphorylation site of serine 301 (D-F-S(p)-P-V) derived from Human Chk1. |
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Full name: |
checkpoint kinase 1 |
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Synonyms： |
CHK1 |
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SwissProt: |
O14757 |
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WB Predicted band size: |
54 kDa |
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WB Positive control: |
K562 cells lysates treated with Na3VO4 |
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WB Recommended dilution: |
500-1000 |
