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Background: |
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. |
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Applications: |
IHC, IF |
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Name of antibody: |
CHD4 |
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Immunogen: |
Synthesized peptide derived from internal of human CHD4. |
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Full name: |
chromodomain helicase DNA binding protein 4 |
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Synonyms： |
chromodomain helicase DNA binding protein 4 |
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SwissProt: |
Q14839 |
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IHC positive control: |
Human liver carcinoma tissue |
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IHC Recommend dilution: |
50-100 |
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IF positive control: |
HepG2 cells |
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IF Recommend dilution: |
100-500 |
