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Background: |
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. |
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Applications: |
WB |
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Name of antibody: |
LAT(Ab-255) |
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Immunogen: |
Synthesized non-phosphopeptide derived from human LAT around the phosphorylation site of tyrosine 255. |
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Full name: |
linker for activation of T cells |
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Synonyms： |
LAT1; pp36 |
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SwissProt: |
O43561 |
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WB Predicted band size: |
28 kDa |
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WB Positive control: |
293 cells lysate |
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WB Recommended dilution: |
500-3000 |
