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021-54845833/15800441009
技术规格
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Background: |
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
KDM7A |
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Immunogen: |
Synthetic peptide of human KDM7A |
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Full name: |
lysine demethylase 7A |
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Synonyms: |
JHDM1D |
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SwissProt: |
Q6ZMT4 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human thyroid cancer and Human ovarian cancer |
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IHC Recommend dilution: |
30-150 |
